Rite Care Pharmacy

Integrative Therapeutics Inc.
Cortisol Manager - 90 Tablet

Reduces cortisol levels for all-day stress reduction and restful sleep. Cortisol Manager combines stress-reducing ingredients and cortisol-lowering botanicals to help reduce stress and relieve occasional sleeplessness. This safe, natural and non-habit forming formula increases the ability to fall asleep, stay asleep, and will not cause morning grogginess, while providing all-day stress reduction - 90 Tablet

Cortisol Manager
stress reducing sleep aid 
Reduces cortisol levels for all-day stress reduction and restful sleep.†


Why a natural sleep aid that manages stress?†
Because a good day starts with a good night.†

A sound night's sleep leads to an increase in daytime alertness, reaction time, and a positive mood.†

Sufficient sleep also gives you the energy to complete your daily activities.†

Everyday stressors cause stress hormones in the body to become elevated. Specific herbs have been clinically shown to reduce stress hormone levels and support the body's relaxation response.†

Why use Cortisol Manager?
It reduces stress - fast!†

Cortisol is a hormone activated by stress. A 28-day trial found that Cortisol Manager produced a dramatic reduction in stress during the course of the study.† In fact, salivary cortisol levels decreased by more than 60% after the first dose of Cortisol Manager.

It increases the ability to fall asleep and stay asleep - without morning grogginess - while providing all-day stress reduction.†

Cortisol Manager combines proprietary stress-reducing ingredient and cortisol-lowering botanical blends to help reduce stress and relieve occasional sleeplessness.†


For adults, take 1 tablet before bedtime. Increase to 2 tablets during times of high stress. Safe for use every night.

Pill Size


Interactions and Depletions

Supplement Facts / Ingredients
Total Carbohydrate <1g <1%**

Sodium 5mg <1%**

Stress-Reducing Proprietary Blend 250mg *

Cortisol-Reducing Proprietary Blend† 225mg *

Phosphatidylserine 50mg *

This product does not contain

  • artificial flavoring
  • corn
  • dairy products
  • gluten
  • ingredients of animal origin
  • preservatives
  • wheat
  • yeast

All colors used are from natural sources.


Caution: Drowsiness may occur. Avoid driving, operating heavy machinery, or consuming alcohol while using this product. If pregnant, nursing, taking prescription drugs, or if you suffer with chronic insomnia, consult your healthcare practitioner prior to use. Keep out of reach of children.

Sensoril® is protected under U.S. Patent 6,713,092 and is a trademark of Natreon, Inc. Suntheanine®, a patented form of L-Theanine, is a trademark of Taiyo International, Inc.

Manufactured by an FDA-registered Drug Establishment.

**Based on 2000 calorie diet.Other Ingredients: dextrose, cellulose, modified cellulose gum, modified cellulose, magnesium stearate, stearic acid, titanium dioxide color, soy lecithin, vegetable glycerin, and carnauba wax.

UPC Codes: 871791004337

Technical Data


Cortisol Manager dietary supplement has been clinically shown to reduce cortisol levels. The supplement combines an effective dose of phosphatidylserine with documented stress-reducing ingredients and cortisol-lowering botanicals to help relieve occasional sleeplessness at night while also providing all-day stress reduction. Cortisol Manager promotes relaxation and supports a healthy sleep cycle without the use of habit forming ingredients. This safe and natural formula increases the ability to fall asleep, stay asleep, and will not cause morning grogginess.

Cortisol Manager:

  • Patented ingredients
    • Sensoril® brand Ashwagandha, US Patent 6,713,092
    • Suntheanine® brand L-Theanine, US Patent Nos. 6,589,566 & 6,297,280
  • Clinically effective level of phosphatidylserine
  • Fast acting formulation “ Reduced cortisol levels after only 24 hours
  • Safe and effective “ No morning grogginess and no habit-forming ingredients

How Does It Work?

The Cortisol Connection

Cortisol, often referred to as the śstress hormoneť, is produced by the adrenal cortex in response to stress. Cortisol is therefore intricately involved in many physiological functions, including the regulation of healthy blood sugar metabolism, maintenance of healthy blood pressure levels already within normal limits, establishment of healthy immune system function, and promotion of the body's natural anti-inflammatory response.†1

When exposed to internal or external stress, the brain sends a message to the adrenal glands to increase cortisol secretion. The body responds by providing a surge in energy, increasing mental alertness, and raising blood pressure, thereby preparing the body for the śfight-or-flightť response.1

While this response provides an effective mechanism for combating an acute stressor, increased or prolonged exposure to stress can lead to elevated cortisol levels. And heightened cortisol, in turn, can lead to changes in body chemistry, altering the balance of hormones and affecting the systems of the body. Research has shown that maintaining healthy cortisol levels can reduce stress, relieve occasional sleeplessness and fatigue, and optimize immune system and neurological function.†2-4

Cortisol Manager Clinical Study

The effectiveness of Cortisol Manager dietary supplement was examined in an open label clinical trial involving 21 healthy volunteers. The combination was taken each night, and results were assessed using salivary cortisol measurements as well as self-assessment questionnaires.

The 28-day trial found that Cortisol Manager produced a dramatic reduction in stress during the course of the study. Salivary cortisol levels decreased by more than 60% after the first dose of Cortisol Manager. The effect continued throughout the duration of the study, averaging a 75-83% reduction in cortisol. No side effects were noted, and the formula was well tolerated by participants.5

Additionally, the participant survey revealed that:5

  • 71% of participants felt more relaxed during the day
  • 71% experienced improved sleep
  • 64% achieved deeper sleep, while 57% felt they fell asleep more easily
  • 57% felt their stress level was reduced
  • 57% felt they were better able to handle stressful situations

The following chart summarizes the benefits of each of the ingredients in Cortisol Manager:

Ashwagandha (Withania somnifera)Several studies have shown that ashwagandha enhances energy levels and stress resistance.†6-8 The herb reduces levels of corticosterone, a stress hormone closely related to cortisol.†9 Research has also documented ashwagandha's mood-enhancing effects.†10 In addition, ashwagandha helps promote healthy immune system function by increasing red and white blood cell counts and platelet counts†11
L-TheanineL-theanine is an amino acid known to promote relaxation and stress reduction by inducing muscle relaxation, reducing occasional anxiety, and maintaining blood pressure already within normal limits. L-theanine increases the activity of alpha brain waves “ the type associated with increased feelings of relaxation.†12 It also increases the concentration of certain neurotransmitters, including serotonin and dopamine, which promote muscle relaxation and provide relief for occasional sleeplessness.†13, 14
Magnolia (Magnolia officinalis)Magnolia has been clinically shown to increase relaxation and enhance stress reduction. Seventy-eight percent of study participants rated magnolia extract as śhighly effectiveť in inducing relaxation; 74 percent felt that magnolia induced restful sleep and was non-sedating.†15 Magnolol and honokiol extracts, derived from magnolia, have also been shown to relieve occasional nervousness.†16, 17
Epimedium (Epimedium koreanum)Epimedium koreanum has been shown to significantly inhibit the activity of cholinesterase, an enzyme which breaks down the acetylcholine neurotransmitter. This ability preserves acetylcholine concentrations in the brain yielding neuroprotective effects.†18
PhosphatidylserineExtracted from soy lecithin, phosphatidylserine has been clinically shown to significantly reduce serum adrenocorticotropin (ACTH) and cortisol levels and salivary cortisol levels following mental stress.†19 It also reduces plasma levels of epinephrine, norepinephrine, ACTH and cortisol after exposure to physical stress.†20 This phospholipid is a critical structural component of neuronal cells and helps promote a positive mood, by decreasing feelings of stress.†21


Cortisol Manager dietary supplement has been clinically shown to promote stress-relief and quality sleep by significantly reducing levels of cortisol, the stress hormone. This safe and natural formulation promotes relaxation with no habit-forming ingredients and no morning grogginess. Long-term use supports healthy cortisol levels, which in turn can help reduce stress, relieve occasional sleeplessness and fatigue, and optimize immune system and neurological function.


For adults, take one tablet before bedtime. Increase to two tablets during times of high stress.


This product will relax you and drowsiness may occur. Avoid driving, operating heavy machinery or consuming alcoholic drinks while using this product. If pregnant, nursing, taking prescription drugs or if you suffer with chronic insomnia consult your healthcare practitioner prior to use.

If you are pregnant, nursing, or taking prescription drugs, consult your healthcare practitioner prior to use.

How Is It Supplied?

  • 70453; 30 tablets
  • 70459; 90 tablets

Storage Recommendations

Store at controlled room temperature, 59° to 86°F (15° “ 30°C).


  1. Lehne RA. Glucocorticoids. In: Pharmacology for Nursing Care, 3rd ed. Philadelphia, Pa: WB Saunders, 1998:616-8.
  2. Melamed S, Ugarten U, Shirom A, Kahana L, Lerman Y, Froom P. Chronic burnout, somatic arousal and elevated salivary cortisol levels. J Psychosom Res. 1999 Jun;46(6):591-8.
  3. Capaldi Ii VF, Handwerger K, Richardson E, Stroud LR. Associations between sleep and cortisol responses to stress in children and adolescents: a pilot study. Behav Sleep Med. 2005;3(4):177-92.
  4. Prinz PN, Bailey SL, Woods DL. Sleep impairments in healthy seniors: roles of stress, cortisol, and interleukin-1 beta. Chronobiol Int. 2000 May;17(3):391-404.
  5. An open label pilot study of the safety and effectiveness of a cortisol-reducing combination in healthy adults. 2006. Unpublished.
  6. Mishra LC, Singh BB, Dagenais S. Scientific basis for the therapeutic use of withania somnifera (Ashwagandha): a review. Altern Med Rev. 2000;5(4):334-346.
  7. Archana R, Namasiviayam A. Antistressor effect of withania somnifera. J Ethnopharm. 1999;64:91-93.
  8. Bhattacharya A. Anti-oxidant effect of Withania somnifera glycowithanolides in chronic footshock stress-induced perturbations of oxidative free radical scavenging enzymes and lipid peroxidation in rat frontal cortex and striatum. J Ethnopharmacol. 2001 Jan;74(1):1-6.
  9. Bhattacharya SK. Adaptogenic activity of Withania somnifera: an experimental study using a rat model of chronic stress. Pharmacol Biochem Behav. 2003 Jun;75(3):547-55.
  10. Bhattacharya SK. Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: an experimental study. Phytomedicine. 2000;7(6):463-9.
  11. Ziauddin M. Studies on the immunomodulatory effects of Ashwagandha. J Ethnopharmacol. 1996;50:69-76.
  12. Ito K. Effect of l-theanine on the release of alpha-brain waves in human volunteers. Nippon Nogeikagaku Kaishi. 1998;72:153-157.
  13. Juneja LR, Chu DC, Okubo T, Nagato Y, Yokogoshi H. L-theanine - a unique amino acid of green tea and it's relaxation effect in humans. Trends in Food Science & Technology. 1999;10:199-204.
  14. Yokogoshi H, Mochizuki M, Saitoh K. Theanine-induced reduction of brain serotonin concentration in rats. Biosci Biotechnol Biochem. 1998 Apr;62(4):816-7.
  15. Compositions and methods of use for extracts of magnoliaceae plants. United States Patent number 6,814,987. November 9, 2004.
  16. Kuribara H. The anxiolytic effect of two oriental herbal drugs in Japan attributed to honokiol from magnolia bark. J Pharm Pharmacol. 2000 Nov;52(11):1425-9.
  17. Kuribara H, Stavinoha WB, Maruyama Y. Honokiol, a putative anxiolytic agent extracted from magnolia bark, has no diazepam-like side-effects in mice. J Pharm Pharmacol. 1999 Jan;51(1):97-103.
  18. Oh MH, Houghton PJ, Whang WK, Cho JH. Screening of Korean herbal medicines used to improve cognitive function for anti-cholinesterase activity. Phytomedicine. 2004 Sep;11(6):544-8.
  19. Hellhammer J. Effects of soy lecithin phosphatidic acid and phosphatidylserine complex (PAS) on the endocrine and psychological responses to mental stress. Stress. 2004 Jun;7(2):119-26.
  20. Monteleone P. Effects of phosphatidylserine on the neuroendocrine response to physical stress in humans. Neuroendocrinology. 1990 Sep;52(3):243-8.
  21. Benton D. The influence of phosphatidylserine supplementation on mood and heart rate when faced with an acute stressor. Nutr Neurosci. 2001;4(3):169-78.

This statement has not been evaluated by the Food and Drug Administration.
   This product is not intended to diagnose, treat, cure, or prevent any disease.

Cortisol Manager - 90 Tablet

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